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  • BSI
    BS EN ISO 21676:2021 Water quality. Determination of the dissolved fraction of selected active pharmaceutical ingredients, transformation products and other organic substances in water and treated waste water. Method using high performance liquid chromatography and mass spectrometric detection (HPLC-MS/MS or -HRMS) after direct injection
    Edition: 2021
    $418.55
    / user per year

Description of BS EN ISO 21676:2021 2021

This document specifies a method for the determination of the dissolved fraction of selected active pharmaceutical ingredients and transformation products, as well as other organic substances (see Table 1) in drinking water, ground water, surface water and treated waste water.

The lower application range of this method can vary depending on the sensitivity of the equipment used and the matrix of the sample. For most compounds to which this document applies, the range is ≥ 0,025 µg/l for drinking water, ground water and surface water, and ≥ 0,050 µg/l for treated waste water.

The method can be used to determine further organic substances or in other types of water (e.g. process water) provided that accuracy has been tested and verified for each case, and that storage conditions of both samples and reference solutions have been validated. Table 1 shows the substances for which a determination was tested in accordance with the method. Table E.1 provides examples of the determination of other organic substances.

Table 1

Substances for which a determination was tested in accordance with this method

Common name
Chemical name (IUPACa ) 		Molecular
formula 		Molar
mass 		CAS-RNb
    g/mol  
4-Acetylaminoantipyrine

N-(2,3-Dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl)acetamide

 C13H15N3O2 245,28 83-15-8
N4-Acetyl sulfamethoxazole

N-{4-[(5-Methyl-1,2-oxazol-3-yl)sulfamoyl]phenyl}-acetamide

 C12H13N3O4S 295,32 21312-10-7
Diatrizoic acid (amidotricoic acid)

3,5-Bis(acetamido)-2,4,6-triiodobenzoic acid

 C11H9I3N2O4 613,91 117-96-4
Atenolol

(RS)-2-[4-[2-Hydroxy-3-(1-methylethylamino) propoxy]phenyl]ethanamide

 C14H22N2O3 266,34 29122-68-7
Bezafibrate

2-{4-[2-(4-Chlorbenzamido)ethyl]phenoxyl}-2-
methylpropanoic acid

 C19H20ClNO4 361,80 41859-67-0
Bisoprolol

(RS)-1-[4-(2-Isopropoxyethoxymethyl)phenoxy]-3-
isopropylamino-2-propanol

 C18H31NO4 325,45 66722-44-9
Carbamazepine

5H-Dibenzo[b,f]azepine-5-carbamide

 C15H12N2O 236,27 298-46-4
Clarithromycin

(2R,3R,4S,5R,8R,9S,10S,11R,12R,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-5-ethyl-3,4-dihydroxy-9-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl]oxy-12-methoxy-2,4,8,10,12,14-hexa-
methyl-6-oxacyclotetradecane-1,7-dione

 C38H69NO13 747,95 81103-11-9
Clofibric acid

2-(4-Chlorophenoxy)-2-methylpropanoic acid

 C10H11ClO3 214,70 882-09-7
Dehydrato-Erythromycin (anhydro-erythromycin)

(2R,3R,4S,5S,8R,9S,10S,11R,12R)-11-{[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-5-ethyl-3-hydroxy-9-[(5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy]-2,4,8,10,12,14-hexamethyl-6,15,16-trioxatricyclo[10.2.1.1{1,4}]hexadecane-7-one

 C37H65NO12 715,91 23893-13-2
Diazepam

(RS)-7-Chlor-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-
benzodiazepine-2-on

 C16H13ClN2O 284,74 439-14-5
Diclofenac

2-[2-[(2,6-Dichlorphenyl)amino]phenyl]acetic acid

 C14H11Cl2NO2 296,15 15307-86-5
10,11-Dihydro-10,11-dihydroxy carbamazepine

(5S,6S)-5,6-Dihydroxy-5,6-dihydrobenzo[b][1]benzazepie-11-carboxamide

 C15H14N2O3 270,29 58955-93-4
Erythromycin

6-(4-Dimethylamino-3-hydroxy-6-methyl-oxan-2-yl)oxy-14-ethyl-7,12,13-trihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl)-oxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione

 C37H67NO13 733,93 114-07-8
4-Formylaminoantipyrine

N-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)formamide

 C12H13N3O2 231,25 1672-58-8
Gemfibrozil

5-(2,5-Chlorophenoxy)-2,2-methylpropanoic acid

 C15H22O3 250,34 25812-30-0
Ibuprofen

(RS)-2-[4-(2-Methylpropyl)phenyl]propanoic acid

 C13H18O2 206,28 15687-27-1
Iomeprol

(±)-N,N′-Bis-(2,3-dihydroxypropyl)-5-[(2-hydroxy-acetyl)methylamino]-2,4,6-triiodo isophthalamide

 C17H22I3N3O8 777,09 78649-41-9
Iopamidol

(S)-N,N′-Bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxypropanoyl)amino]-2,4,6-triiodobenzene-1,3-dicarbamide

 C17H22I3N3O3 777,08 60166-93-0
Iopromide

(±)-N,N′-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-
(2-methoxyacetamido)-N-methylisophthalamide

 C18H24I3N3O8 791,12 73334-07-3
Metoprolol

(RS)-1-(Isopropylamino)-3-[4-(2-methoxyethyl) phenoxy]propan-2-ol

 C15H25NO3 267,36 37350-58-6
Naproxen

(S)-2-(6-Methoxy-2-naphthyl)propanoic acid

 C14H14O3 230,26 22204-53-1
Oxazepam

(RS)-7-Chloro-3-hydroxy-5-phenyl-1,3-dihydro-2H-1,4-
benzodiazepin-2-on

 C15H11ClN2O2 286,71 604-75-1
Phenazone

1,5-Dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-on

 C11H12N2O 188,23 60-80-0
Primidone

5-Ethyl-5-phenylhexahydropyrimidin-4,6-dione

 C12H14N2O2 218,25 125-33-7
Propyphenazone

1,5-Dimethyl-4-(1-methylethyl)-2-phenyl-1,2-dihydro-3H-
pyrazol-3-one

 C14H18N2O 230,31 479-92-5
Roxithromycin

(3R,4S,5S,6R,7R,9R,11S,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,7,9,11,13-hexamethyl-10-(2,4,7-trioxa-1-azaoctan-1-ylidene)-1-
oxacyclotetradecane-2-one

 C41H76N2O15 837,05 80214-83-1
Sotalol

(RS)-4′-(1-Hydroxy-2-isopropylaminoethyl)
methanesulfonanilide

 C12H20N2O3S 272,36 3930-20-9
Sulfamethoxazole

4-Amino-N-(5-methyl-1,2-oxazol-3-yl)benzene-sulfonamide

 C10H11N3O3S 253,28 723-46-6
Temazepam

(RS)-7-Chloro-3-hydroxy-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

 C16H13ClN2O2 300,74 846-50-4
Trimethoprim

2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine

 C14H18N4O3 290,32 738-70-5

a IUPAC: International Union of Pure and Applied Chemistry.

b CAS-RN: Chemical Abstracts System Registration Number.



Standard NumberBS EN ISO 21676:2021
TitleWater quality. Determination of the dissolved fraction of selected active pharmaceutical ingredients, transformation products and other organic substances in water and treated waste water. Method using high performance liquid chromatography and mass spectrometric detection (HPLC-MS/MS or -HRMS) after direct injection
StatusDefinitive
Publication Date2021-08-11
Identical National Standard OfISO 21676:2018, EN ISO 21676:2021
CorrectsBS ISO 21676:2018
DescriptorsTest specimens, Potable water, Quality, Chemical analysis and testing, Containers, Preservation, Water testing, Water, Biological analysis and testing, Laboratory testing, Water treatment, Samples
ICS13.060.50 Examination of water for chemical substances
CommitteeEH/3/2
ISBN978 0 539 16731 3
PublisherBSI
Pages44

About BSI

BSI Group, also known as the British Standards Institution is the national standards body of the United Kingdom. BSI produces technical standards on a wide range of products and services and also supplies certification and standards-related services to businesses.
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