ASTM F749-98(2012)
Historical Standard: ASTM F749-98(2012) Standard Practice for Evaluating Material Extracts by Intracutaneous Injection in the Rabbit
SUPERSEDED (see Active link, below)
ASTM F749
1. Scope
1.1 This practice is a nonspecific, acute toxicity test used to help determine the biocompatibility of materials used in medical devices.
1.2 The liquids injected into the rabbits are those obtained by Practice F619 where the extraction vehicles are saline, vegetable oil, or other liquids simulating human body fluids.
1.3 This practice is one of several developed for the assessment of the biocompatibility of materials. Practice F748 may provide guidance for the selection of appropriate methods for testing materials for a specific application.
1.4 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard.
2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.
ASTM Standards
F619 Practice for Extraction of Medical Plastics
F748 Practice for Selecting Generic Biological Test Methods for Materials and Devices
Keywords
acute toxicity tests; biocompatibility; intracutaneous injection; rabbits; test animals ;
ICS Code
ICS Number Code 11.220 (Veterinary medicine)
DOI: 10.1520/F0749-98R12
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