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  • BSI
    BS ISO 19040-1:2018 Water quality. Determination of the estrogenic potential of water and waste water - Yeast estrogen screen (Saccharomyces cerevisiae)
    Edition: 2018
    $526.05
    / user per year

Description of BS ISO 19040-1:2018 2018

This document specifies a method for the determination of the estrogenic potential of water and waste water by means of a reporter gene assay with genetically modified yeast strains Saccharomyces cerevisiae. This reporter gene assay is based on the activation of the human estrogen receptor alpha.

This method is applicable to:

  • fresh water;

  • waste water;

  • aqueous extracts and leachates;

  • eluates of sediments (fresh water);

  • pore water;

  • aqueous solutions of single substances or of chemical mixtures;

  • drinking water.

The limit of quantification (LOQ) of this method for the direct analysis of water samples is between 8 ng/l and 15 ng/l 17β-estradiol equivalents (EEQ) based on the results of the international interlaboratory trial (see Annex F). The upper threshold of the dynamic range for this test is between 120 ng/l and 160 ng/l 17β-estradiol equivalents (EEQ). Samples showing estrogenic potencies above this threshold have to be diluted for a valid quantification. Extraction and pre-concentration of water samples can prove necessary, if their estrogenic potential is below the given LOQ.



Standard NumberBS ISO 19040-1:2018
TitleWater quality. Determination of the estrogenic potential of water and waste water - Yeast estrogen screen (Saccharomyces cerevisiae)
StatusWithdrawn
Publication Date2018-08-10
Withdrawn Date2022-10-11
Identical National Standard OfISO 19040-1:2018
DescriptorsYeast, Water, Quality, Microbiological analysis, Organism-activity determination, Assay, Genes
ICS13.060.70 Examination of biological properties of water
CommitteeEH/3/5
ISBN978 0 580 84720 2
PublisherBSI
Pages60

About BSI

BSI Group, also known as the British Standards Institution is the national standards body of the United Kingdom. BSI produces technical standards on a wide range of products and services and also supplies certification and standards-related services to businesses.
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